Issue 34, 2017

Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Abstract

A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et3N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

Graphical abstract: Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2017
Accepted
09 Aug 2017
First published
09 Aug 2017

Org. Biomol. Chem., 2017,15, 7218-7226

Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

Y. Xi, G. Zhu, L. Tang, S. Ma, D. Zhang, R. Zhang, G. He and H. Zhu, Org. Biomol. Chem., 2017, 15, 7218 DOI: 10.1039/C7OB01470H

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