Issue 28, 2017

Dual visible-light photoredox and palladium(ii) catalysis for dehydrogenative C2-acylation of indoles at room temperature

Abstract

A highly regioselective direct C2-acylation of N-pyrimidine protected indoles with aldehydes is reported at room temperature through the merger of visible light photoredox and palladium(II) catalysis. Late-stage acylation of tryptophan, selective mono-acylation of carbazole and the syntheses of tubulin inhibitors D-64131 and D-68144 are also demonstrated.

Graphical abstract: Dual visible-light photoredox and palladium(ii) catalysis for dehydrogenative C2-acylation of indoles at room temperature

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2017
Accepted
27 Jun 2017
First published
27 Jun 2017

Org. Biomol. Chem., 2017,15, 5899-5903

Dual visible-light photoredox and palladium(II) catalysis for dehydrogenative C2-acylation of indoles at room temperature

M. K. Manna, G. Bairy and R. Jana, Org. Biomol. Chem., 2017, 15, 5899 DOI: 10.1039/C7OB01418J

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