Issue 16, 2017

Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis

Abstract

A concise and enantioselective synthesis of the tetracyclic indoles, including the naturally occurring compounds (+)-arborescidine C and (+)-arborescidine B, was achieved by the key step of Pictet–Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst. The synthetic process was further demonstrated in a pot-economy strategy and was achieved in a one-pot operation.

Graphical abstract: Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2017
Accepted
29 Mar 2017
First published
29 Mar 2017

Org. Biomol. Chem., 2017,15, 3408-3412

Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis

V. M. Sheth, B. Hong and G. Lee, Org. Biomol. Chem., 2017, 15, 3408 DOI: 10.1039/C7OB00473G

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