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Issue 14, 2017
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Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

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Abstract

Pd(t-Bu3P)2 has been successfully identified as an efficient catalyst for the hydroaminocarbonylation of aromatic alkenes to branched amides under relatively mild reaction conditions. With hydroxylamine hydrochloride as an additive, both aliphatic and aromatic amines could be used as coupling partners for the present reaction, leading to production of branched amides in high yields with excellent regioselectivities.

Graphical abstract: Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

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Publication details

The article was received on 15 Feb 2017, accepted on 13 Mar 2017 and first published on 22 Mar 2017


Article type: Communication
DOI: 10.1039/C7OB00371D
Citation: Org. Biomol. Chem., 2017,15, 2910-2913
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    Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

    J. Zhu, B. Gao and H. Huang, Org. Biomol. Chem., 2017, 15, 2910
    DOI: 10.1039/C7OB00371D

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