Issue 17, 2017

An Ir(iii)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

Abstract

An Ir(III)-catalyzed relay aryl C–H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed. This method provides an efficient approach to multifunctionalized 1,3-dihydroindol-2-ones with a broad range of functional group tolerance. Furthermore, this protocol could be applied for the concise synthesis of bioactive hematopoietic growth factor analogues.

Graphical abstract: An Ir(iii)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

Supplementary files

Article information

Article type
Paper
Submitted
15 Feb 2017
Accepted
03 Apr 2017
First published
03 Apr 2017

Org. Biomol. Chem., 2017,15, 3638-3647

An Ir(III)-catalyzed aryl C–H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones

S. Bai, X. Chen, X. Hu, Y. Deng, H. Jiang and W. Zeng, Org. Biomol. Chem., 2017, 15, 3638 DOI: 10.1039/C7OB00367F

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