Metal-free decarbonylative alkylation–aminoxidation of styrene derivatives with aliphatic aldehydes and N-hydroxyphthalimide

Abstract

A convenient metal-free decarbonylative alkylation–aminoxidation of styrene derivatives with aliphatic aldehydes and N-hydroxyphthalimide (NHPI) to yield phthalimide protected alkoxyamines is developed. With DTBP as an oxidant and radical-initiator, this reaction smoothly converts aliphatic aldehydes into alkyl radicals and subsequently allows the cascade construction of C(sp³)–C(sp³) and C(sp³)–O bonds via radical–radical coupling.