N-Heterocyclic carbene–palladium(ii)–1-methylimidazole complex catalyzed direct C–H bond arylation of imidazo[1,2-a]pyridines with aryl chlorides

Abstract

We herein reported the N-heterocyclic carbene–palladium(II)–1-methylimidazole complex catalyzed direct C–H bond arylation of imidazo[1,2-a]pyridines with aryl chlorides. Under suitable conditions, all reactions between various imidazo[1,2-a]pyridines and aryl chlorides worked well to give the desired C3–H arylated products in acceptable to high yields, giving a convenient and alternative method for the direct C–H bond arylation of imidazo[1,2-a]pyridines, using economic and easily available aryl chlorides as the arylating reagents.