Jump to main content
Jump to site search

Issue 38, 2016
Previous Article Next Article

Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea

Author affiliations

Abstract

A highly efficient phospha-aldol reaction for the synthesis of α1-oxindole-α-hydroxyphosphonates is developed utilizing N-heterocyclic phosphine (NHP)-thiourea as a phosphonylation reagent under catalyst, additive free conditions. This methodology encompasses a variety of isatin derivatives to provide α1-oxindole- α-hydroxyphosphonates up to 99% yield.

Graphical abstract: Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jul 2016, accepted on 09 Sep 2016 and first published on 09 Sep 2016


Article type: Communication
DOI: 10.1039/C6OB01608A
Citation: Org. Biomol. Chem., 2016,14, 8952-8956
  •   Request permissions

    Catalyst-free synthesis of α1-oxindole-α-hydroxyphosphonates via phospha-aldol reaction of isatins employing N-heterocyclic phosphine (NHP)-thiourea

    N. Molleti and J. Yong Kang, Org. Biomol. Chem., 2016, 14, 8952
    DOI: 10.1039/C6OB01608A

Search articles by author

Spotlight

Advertisements