Issue 29, 2016

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

Abstract

A general and efficient methodology for preparing primary sulfonamides has been developed. In the presence of iodine as the catalyst and TBHP (70% in water) as the oxidant, a wide range of primary sulfonamides were prepared from the corresponding thiols and aqueous ammonia in moderate to good yields.

Graphical abstract: A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2016
Accepted
28 Jun 2016
First published
28 Jun 2016

Org. Biomol. Chem., 2016,14, 6951-6954

A general iodine-mediated synthesis of primary sulfonamides from thiols and aqueous ammonia

J. Feng and X. Wu, Org. Biomol. Chem., 2016, 14, 6951 DOI: 10.1039/C6OB01301E

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