Issue 40, 2015

A hybridisation-dependent membrane-insertable amphiphilic DNA

Abstract

We synthesised a novel membrane-insertable amphiphilic DNA. The amphiphilic DNA had a nine-nucleotide hydrophobic region at one end consisting of octyl phosphotriester linkages. The amphiphilic DNA bound to the lipid membrane by inserting the hydrophobic region; this process was facilitated by the presence of the complementary DNA strand.

Graphical abstract: A hybridisation-dependent membrane-insertable amphiphilic DNA

Supplementary files

Article information

Article type
Communication
Submitted
22 Aug 2015
Accepted
09 Sep 2015
First published
15 Sep 2015

Org. Biomol. Chem., 2015,13, 10117-10121

A hybridisation-dependent membrane-insertable amphiphilic DNA

C. Dohno, K. Matsuzaki, H. Yamaguchi, T. Shibata and K. Nakatani, Org. Biomol. Chem., 2015, 13, 10117 DOI: 10.1039/C5OB01761K

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