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Issue 40, 2015
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Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives

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Abstract

An efficient and practical one-pot domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives from readily available 2-(2-bromophenyl)acetonitriles was developed. The overall protocol involves a Buchwald–Hartwig type coupling and a base-promoted intramolecular nucleophilic reaction. The reaction scope, advantages and limitations are discussed.

Graphical abstract: Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives

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Publication details

The article was received on 06 Aug 2015, accepted on 07 Sep 2015 and first published on 07 Sep 2015


Article type: Communication
DOI: 10.1039/C5OB01642H
Citation: Org. Biomol. Chem., 2015,13, 10122-10126
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    Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives

    M. Jiang, H. Xiang, F. Zhu, X. Xu, L. Deng and C. Yang, Org. Biomol. Chem., 2015, 13, 10122
    DOI: 10.1039/C5OB01642H

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