Issue 25, 2015
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines†

Hao Xie,a   Yunfeng Liao,a   Shuqing Chen,a   Ya Chena  and  Guo-Jun Deng*ab  

* Corresponding authors

a Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China
E-mail: gjdeng@xtu.edu.cn
Fax: (+86)-731-58292251

b Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China

Abstract

A novel Cu-catalyzed direct amidation of 2-methylquinolines with amines is described. This method afforded an efficient approach for the synthesis of biologically important aromatic amides from readily available coupling partners using molecular oxygen as the oxidant.

Graphical abstract: Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines

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Article information

DOI
https://doi.org/10.1039/C5OB00915D
Article type
Communication
Submitted
06 May 2015
Accepted
21 May 2015
First published
21 May 2015

Org. Biomol. Chem., 2015,13, 6944-6948

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Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines

H. Xie, Y. Liao, S. Chen, Y. Chen and G. Deng, Org. Biomol. Chem., 2015, 13, 6944 DOI: 10.1039/C5OB00915D

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