Issue 27, 2015

Fluorinated enol ethers: their synthesis and reactivity

Abstract

Thanks to the beneficial effect of fluorine substitution on the pharmacokinetic properties of molecules, an ever increasing number of marketed drugs incorporate a fluorine atom into their structure. As a consequence, the synthesis of fluorinated molecules has become a very active research field. Among the numerous approaches, fluorinated enol ethers are valuable building blocks that allow the introduction of a fluoro- or difluoromethyl group through a wide variety of reactions. The present review lists different methods for their preparation and sums up their numerous synthetic applications.

Graphical abstract: Fluorinated enol ethers: their synthesis and reactivity

Article information

Article type
Review Article
Submitted
28 Apr 2015
Accepted
28 May 2015
First published
28 May 2015

Org. Biomol. Chem., 2015,13, 7351-7380

Author version available

Fluorinated enol ethers: their synthesis and reactivity

M. Decostanzi, J.-M. Campagne and E. Leclerc, Org. Biomol. Chem., 2015, 13, 7351 DOI: 10.1039/C5OB00855G

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