Issue 20, 2015

The tale of RNA G-quadruplex

Abstract

G-quadruplexes are non-canonical secondary structures found in guanine rich regions of DNA and RNA. Reports have indicated the wide occurrence of RNA G-quadruplexes across the transcriptome in various regions of mRNAs and non-coding RNAs. RNA G-quadruplexes have been implicated in playing an important role in translational regulation, mRNA processing events and maintenance of chromosomal end integrity. In this review, we summarize the structural and functional aspects of RNA G-quadruplexes with emphasis on recent progress to understand the protein/trans factors binding these motifs. With the revelation of the importance of these secondary structures as regulatory modules in biology, we have also evaluated the various advancements towards targeting these structures and the challenges associated with them. Apart from this, numerous potential applications of this secondary motif have also been discussed.

Graphical abstract: The tale of RNA G-quadruplex

Article information

Article type
Review Article
Submitted
29 Dec 2014
Accepted
01 Apr 2015
First published
01 Apr 2015

Org. Biomol. Chem., 2015,13, 5570-5585

Author version available

The tale of RNA G-quadruplex

P. Agarwala, S. Pandey and S. Maiti, Org. Biomol. Chem., 2015, 13, 5570 DOI: 10.1039/C4OB02681K

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