Issue 7, 2015
From the journal:

Organic & Biomolecular Chemistry

Halide inhibition of the copper-catalysed azide–alkyne cycloaddition†

Rebekah M. Moorman,a   Matthew B. Collier,a   Bram H. Frohock,a   Michael D. Womblea  and  Justin M. Chalker*a  

* Corresponding authors

a The University of Tulsa, Department of Chemistry and Biochemistry, 800 South Tucker Drive, Tulsa, Oklahoma 74104, USA
E-mail: justin-chalker@utulsa.edu

Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide–alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction.

Graphical abstract: Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4OB02479F
Article type
Communication
Submitted
25 Nov 2014
Accepted
16 Dec 2014
First published
24 Dec 2014

Org. Biomol. Chem., 2015,13, 1974-1978

Permissions

Request permissions

Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

R. M. Moorman, M. B. Collier, B. H. Frohock, M. D. Womble and J. M. Chalker, Org. Biomol. Chem., 2015, 13, 1974 DOI: 10.1039/C4OB02479F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements