Issue 1, 2015

Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

Abstract

A novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates was synthesized and evaluated by photochemical characterization and cell-based assays. The specific responsiveness to the cytoplasmic entry of the probe was implemented by adopting a disulfide linker, whose cleavage under the reducing conditions of the cytoplasm induced the display of a distinctive fluorescence signal.

Graphical abstract: Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2014
Accepted
22 Oct 2014
First published
22 Oct 2014

Org. Biomol. Chem., 2015,13, 73-76

Author version available

Development of a novel fluorescence probe capable of assessing the cytoplasmic entry of siderophore-based conjugates

H. S. Kim, W. Y. Song and H. J. Kim, Org. Biomol. Chem., 2015, 13, 73 DOI: 10.1039/C4OB01810A

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