Issue 38, 2014

Efficient cobalt-catalyzed C–N cross-coupling reaction between benzamide and aryl iodide in water

Abstract

A practical and efficient strategy for the N-arylation of benzamide catalysed by a Co(C2O4)·2H2O/dmeda system in water is reported. Under the optimized conditions, a wide variety of N-arylated products were obtained in good yields (up to 92%) using substituted aryl iodides.

Graphical abstract: Efficient cobalt-catalyzed C–N cross-coupling reaction between benzamide and aryl iodide in water

Supplementary files

Article information

Article type
Communication
Submitted
15 Jul 2014
Accepted
11 Aug 2014
First published
11 Aug 2014

Org. Biomol. Chem., 2014,12, 7478-7481

Efficient cobalt-catalyzed C–N cross-coupling reaction between benzamide and aryl iodide in water

B. Y. Tan and Y. Teo, Org. Biomol. Chem., 2014, 12, 7478 DOI: 10.1039/C4OB01483A

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