Issue 44, 2014

Directed arene/alkyne annulation reactions via aerobic copper catalysis

Abstract

We describe a straightforward protocol for a smooth dehydrogenative annulation reaction between various arenes and terminal alkynes using a catalytic amount of CuBr2 and molecular oxygen. 3-Methyleneisoindoline derivatives are prepared in high yields.

Graphical abstract: Directed arene/alkyne annulation reactions via aerobic copper catalysis

Supplementary files

Article information

Article type
Paper
Submitted
24 Jun 2014
Accepted
24 Jul 2014
First published
29 Jul 2014

Org. Biomol. Chem., 2014,12, 8844-8850

Directed arene/alkyne annulation reactions via aerobic copper catalysis

Y. Zhang, Q. Wang, H. Yu and Y. Huang, Org. Biomol. Chem., 2014, 12, 8844 DOI: 10.1039/C4OB01312C

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