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Issue 25, 2014
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Nanomolar fluorogenic detection of Al(III) by a series of Schiff bases in an aqueous system and their application in cell imaging

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Abstract

Three positional isomers of a Schiff base containing –OH as end groups have been synthesized and evaluated for selective Al(III) detection due to inhibition of ESIPT, PET and activation of CHEF in 70% aqueous medium. Devoid of any conventional fluorophore, these sensors have nanomolar detection limits with high quantum yields and naked eye sensing of Al(III). Moreover, these probes have been demonstrated to enable the Al(III) detection in live human HeLa cells and rat C6 glioma cells using a confocal microscope.

Graphical abstract: Nanomolar fluorogenic detection of Al(iii) by a series of Schiff bases in an aqueous system and their application in cell imaging

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Publication details

The article was received on 13 Feb 2014, accepted on 29 Apr 2014 and first published on 30 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00329B
Citation: Org. Biomol. Chem., 2014,12, 4445-4453
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    Nanomolar fluorogenic detection of Al(III) by a series of Schiff bases in an aqueous system and their application in cell imaging

    S. Sharma, M. S. Hundal, A. Walia, V. Vanita and G. Hundal, Org. Biomol. Chem., 2014, 12, 4445
    DOI: 10.1039/C4OB00329B

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