Issue 22, 2014

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.

Graphical abstract: Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Supplementary files

Article information

Article type
Paper
Submitted
28 Jan 2014
Accepted
04 Apr 2014
First published
04 Apr 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2014,12, 3744-3754

Author version available

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

C. Percivalle, C. Sissi, M. L. Greco, C. Musetti, A. Mariani, A. Artese, G. Costa, M. L. Perrore, S. Alcaro and M. Freccero, Org. Biomol. Chem., 2014, 12, 3744 DOI: 10.1039/C4OB00220B

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