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Issue 24, 2014
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Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

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Abstract

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds.

Graphical abstract: Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

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Publication details

The article was received on 22 Jan 2014, accepted on 16 Apr 2014 and first published on 17 Apr 2014


Article type: Paper
DOI: 10.1039/C4OB00175C
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Citation: Org. Biomol. Chem., 2014,12, 4233-4242
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    Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

    A. I. Sánchez, R. Meneses, J. M. Mínguez, A. Núñez, R. R. Castillo, F. Filace, C. Burgos, J. J. Vaquero, J. Álvarez-Builla, A. Cortés-Cabrera, F. Gago, E. Terricabras and V. Segarra, Org. Biomol. Chem., 2014, 12, 4233
    DOI: 10.1039/C4OB00175C

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