Issue 15, 2014

Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita–Baylis–Hillman reaction

Abstract

This work demonstrates that, in accord with metal catalysis, ferrocene could be an excellent scaffold for organocatalysts. The simple and easily accessible bifunctional ferrocene-based squaramide-phosphine shows high enantioselectivity in the intramolecular Morita–Baylis–Hillman reaction of 7-aryl-7-oxo-5-heptenals, giving a variety of 2-aroyl-2-cyclohexenols in up to 96% ee.

Graphical abstract: Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita–Baylis–Hillman reaction

Supplementary files

Article information

Article type
Paper
Submitted
19 Jan 2014
Accepted
22 Jan 2014
First published
27 Jan 2014

Org. Biomol. Chem., 2014,12, 2423-2426

Author version available

Bifunctional ferrocene-based squaramide-phosphine as an organocatalyst for highly enantioselective intramolecular Morita–Baylis–Hillman reaction

X. Zhang, P. Ma, D. Zhang, Y. Lei, S. Zhang, R. Jiang and W. Chen, Org. Biomol. Chem., 2014, 12, 2423 DOI: 10.1039/C4OB00137K

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