Issue 12, 2014

A new approach for the synthesis of O-glycopeptides through a combination of solid-phase glycosylation and fluorous tagging chemistry (SHGPFT)

Abstract

Glycoproteins and glycopeptides play important roles in various physiological and pathophysiological processes. Efficient preparation of glycopeptides with a specific structure is one of the pivotal areas in current chemistry research. In this article, a new SHGPFT approach to the synthesis and efficient purification of O-glycosylated peptides is developed by combining a solid-phase glycosylation and a light-fluorous glycosyl donor protocol. The desired product is finally isolated from the side products in the cleaved mixture by an efficient fluorous solid-phase extraction (F-SPE) step.

Graphical abstract: A new approach for the synthesis of O-glycopeptides through a combination of solid-phase glycosylation and fluorous tagging chemistry (SHGPFT)

Supplementary files

Article information

Article type
Paper
Submitted
05 Dec 2013
Accepted
19 Jan 2014
First published
22 Jan 2014

Org. Biomol. Chem., 2014,12, 1892-1896

Author version available

A new approach for the synthesis of O-glycopeptides through a combination of solid-phase glycosylation and fluorous tagging chemistry (SHGPFT)

B. Liu, F. Zhang, Y. Zhang and G. Liu, Org. Biomol. Chem., 2014, 12, 1892 DOI: 10.1039/C3OB42430H

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