Asymmetric α-amination reaction of alkenyl trifluoroacetates catalyzed by a chiral phosphine–silver complex†
Abstract
The asymmetric α-amination of alkenyl trifluoroacetates with dialkyl azodicarboxylates catalyzed by the DTBM-SEGPHOS·AgOTf complex takes place in the presence of 2,2,2-trifluoroethanol with almost quantitative yield and high ees of up to 97%.