Organocatalyzed stereospecific C–C bond formation of β-lactams†
Abstract
Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C–C bond forming reactions.
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* Corresponding authors
a
Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa
E-mail:
govenderthav@ukzn.ac.za
Tel: +27 312601845
b
Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
E-mail:
per.arvidsson@scilifelab.se
Tel: +46 852481398
Herein, we report the development of mild, organocatalyzed routes to novel carbapenam derivatives through aldol, Mannich and Michael C–C bond forming reactions.
S. A. Pawar, S. Alapour, S. Khanyase, Z. E. D. Cele, S. Chitti, H. G. Kruger, T. Govender and P. I. Arvidsson, Org. Biomol. Chem., 2013, 11, 8294 DOI: 10.1039/C3OB41858H
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