Issue 46, 2013

Synthetic applications of arylboronic acid via an aryl radical transfer pathway

Abstract

The transition-metal-catalyzed functionalization of arylboronic acids is the most powerful tool for the formation of carbon–carbon and carbon–heteroatom bonds in modern organic synthesis. These transformations are generally considered to proceed via organometallic intermediates generated by transmetalation from the boronic acids. Interestingly, there is a novel recognition that arylboronic acids can serve as aryl radical precursors via oxidative carbon–boron bond cleavage in recent years. Manganese(III) acetate, Ag(I)/persulfate and iron(II or III)/persulfate catalytic systems have been shown to be effective for this transformation. In this review, recent advances in this new area are highlighted and their mechanisms are also discussed.

Graphical abstract: Synthetic applications of arylboronic acid via an aryl radical transfer pathway

Article information

Article type
Review Article
Submitted
11 Sep 2013
Accepted
08 Oct 2013
First published
09 Oct 2013

Org. Biomol. Chem., 2013,11, 7999-8008

Synthetic applications of arylboronic acid via an aryl radical transfer pathway

G. Yan, M. Yang and X. Wu, Org. Biomol. Chem., 2013, 11, 7999 DOI: 10.1039/C3OB41851K

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