Issue 42, 2013
From the journal:

Organic & Biomolecular Chemistry

Tandem Michael addition/isocyanide insertion into the C–C bond: a novel access to 2-acylpyrroles and medium-ring fused pyrroles†

Lingjuan Zhang,a   Xianxiu Xu,*a   Qiu-rong Shao,b   Ling Pana  and  Qun Liu*a  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun 130024, China
E-mail: xuxx677@nenu.edu.cn, liuqun@nenu.edu.cn

b Shunde Entry-Exit Inspection and Quarantine Bureau Chemical Products Laboratory, Shunde, China

Abstract

A new reaction model, tandem Michael addition/formal isocyanide insertion into the acyl C–C bond, has been developed. Thus, a series of 2-acylpyrroles and seven-/eight-membered ring fused pyrroles were synthesized from the reaction of methyl isocyanides with enones in a single operation.

Graphical abstract: Tandem Michael addition/isocyanide insertion into the C–C bond: a novel access to 2-acylpyrroles and medium-ring fused pyrroles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3OB41793J
Article type
Paper
Submitted
03 Sep 2013
Accepted
09 Sep 2013
First published
24 Sep 2013

Org. Biomol. Chem., 2013,11, 7393-7399

Permissions

Request permissions

Tandem Michael addition/isocyanide insertion into the C–C bond: a novel access to 2-acylpyrroles and medium-ring fused pyrroles

L. Zhang, X. Xu, Q. Shao, L. Pan and Q. Liu, Org. Biomol. Chem., 2013, 11, 7393 DOI: 10.1039/C3OB41793J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements