Issue 45, 2013
From the journal:

Organic & Biomolecular Chemistry

Pd(ii)-catalyzed direct C–H acylation of N-Boc hydrazones with aldehydes: one-pot synthesis of 1,2-diacylbenzenes†

Satyasheel Sharma,a   Aejin Kim,a   Jihye Park,a   Mirim Kim,a   Jong Hwan Kwak,a   Young Hoon Jung,a   Jung Su Park*b  and  In Su Kim*a  

* Corresponding authors

a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

b Department of Chemistry, Sookmyung Women's University, Seoul 140-742, Republic of Korea
E-mail: jspark@sookmyung.ac.kr
Fax: +82 2 2077 7321
Tel: +82 2 2077 7549

Abstract

A palladium(II)-catalyzed direct acylation of acetophenone N-Boc hydrazones with aldehydes via C–H bond activation is described. This protocol provides direct access to a range of 1,2-diacylbenzenes, which are useful precursors to construct biologically interesting and pharmaceutically important compounds.

Graphical abstract: Pd(ii)-catalyzed direct C–H acylation of N-Boc hydrazones with aldehydes: one-pot synthesis of 1,2-diacylbenzenes

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Article information

DOI
https://doi.org/10.1039/C3OB41644E
Article type
Paper
Submitted
12 Aug 2013
Accepted
27 Sep 2013
First published
27 Sep 2013

Org. Biomol. Chem., 2013,11, 7869-7876

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Pd(II)-catalyzed direct C–H acylation of N-Boc hydrazones with aldehydes: one-pot synthesis of 1,2-diacylbenzenes

S. Sharma, A. Kim, J. Park, M. Kim, J. H. Kwak, Y. H. Jung, J. S. Park and I. S. Kim, Org. Biomol. Chem., 2013, 11, 7869 DOI: 10.1039/C3OB41644E

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