Issue 32, 2013
From the journal:

Organic & Biomolecular Chemistry

A fluorogenic assay for screening Sirt6 modulators†

Jing Hu,a   Bin He,a   Shiva Bhargavaa  and  Hening Lin*a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA
E-mail: hl379@cornell.edu
Tel: +1 607-255-4650

Abstract

A fluorogenic high-throughput assay suitable for screening Sirt6 modulators is developed based on the recently discovered efficient activity of Sirt6 to hydrolyze myristoyl lysine. Sirt6 modulators will be useful in investigating the function of Sirt6 and protein lysine fatty acylation.

Graphical abstract: A fluorogenic assay for screening Sirt6 modulators

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3OB41138A
Article type
Communication
Submitted
31 May 2013
Accepted
25 Jun 2013
First published
25 Jun 2013

Org. Biomol. Chem., 2013,11, 5213-5216

Permissions

Request permissions

A fluorogenic assay for screening Sirt6 modulators

J. Hu, B. He, S. Bhargava and H. Lin, Org. Biomol. Chem., 2013, 11, 5213 DOI: 10.1039/C3OB41138A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements