Issue 27, 2013
From the journal:

Organic & Biomolecular Chemistry

Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins†

Detcho A. Stoyanovsky,*a   Melanie J. Scottb  and  Timothy R. Billiarb  

* Corresponding authors

a Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
E-mail: stoyanovskyd@upmc.edu
Fax: +01 412 624 9361
Tel: +01 412 383 6910

b Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA

Abstract

In this study, we present experimental evidence that glutathione acts in concert with human thioredoxin type 1 in the denitrosation of cytosolic S-nitrosoproteins (PSNOs) from HepG2 cells.

Graphical abstract: Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins

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DOI
https://doi.org/10.1039/C3OB40809D
Article type
Communication
Submitted
22 Apr 2013
Accepted
31 May 2013
First published
03 Jun 2013

Org. Biomol. Chem., 2013,11, 4433-4437

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Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins

D. A. Stoyanovsky, M. J. Scott and T. R. Billiar, Org. Biomol. Chem., 2013, 11, 4433 DOI: 10.1039/C3OB40809D

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