Issue 34, 2013
From the journal:

Organic & Biomolecular Chemistry

Synergistic effect of additives on cyclopropanation of olefins†

Donghao Cheng,a   Deshun Huanga  and  Yian Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

b Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
E-mail: yian@lamar.colostate.edu
Fax: +001-970-4911801
Tel: +001-970-4917424

Abstract

An efficient cyclopropanation of olefins with Zn(CH2I)2, a catalytic amount of CCl3CO2H, and 1,2-dimethoxyethane at room temperature is described. A wide variety of olefins, including acid-sensitive substrates, can be cyclopropanated in 71–99% yield.

Graphical abstract: Synergistic effect of additives on cyclopropanation of olefins

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Article information

DOI
https://doi.org/10.1039/C3OB40751A
Article type
Communication
Submitted
15 Apr 2013
Accepted
21 Jun 2013
First published
15 Jul 2013

Org. Biomol. Chem., 2013,11, 5588-5591

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Synergistic effect of additives on cyclopropanation of olefins

D. Cheng, D. Huang and Y. Shi, Org. Biomol. Chem., 2013, 11, 5588 DOI: 10.1039/C3OB40751A

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