Issue 30, 2013
From the journal:

Organic & Biomolecular Chemistry

A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies†

Yi Xia,ab   Kheya Sengupta,a   Alain Maggiani,a   Fanqi Qub  and  Ling Peng*a  

* Corresponding authors

a Aix-Marseille University, Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, 163, avenue de Luminy, 13288 Marseille, France
E-mail: ling.peng@univ-amu.fr
Fax: +33 4 91 82 93 01
Tel: +33 4 91 82 91 54

b State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, P. R. China

Abstract

A bola-phospholipid probe, carrying a tetrafluorophenylazido chromophore in the middle of the transmembrane diacyl chain, was synthesized and characterized with a view to studying biomembranes by a photolabeling approach. This probe shows the advantageous stability of bola-lipids in giant vesicle formation alongside excellent photochemical properties conferred by the tetrafluorophenylazido chromophore, and thus constitutes a promising probe for biomembrane photolabeling studies.

Graphical abstract: A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies

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Article information

DOI
https://doi.org/10.1039/C3OB40659H
Article type
Paper
Submitted
03 Apr 2013
Accepted
23 May 2013
First published
23 May 2013

Org. Biomol. Chem., 2013,11, 5000-5005

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A bola-phospholipid bearing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies

Y. Xia, K. Sengupta, A. Maggiani, F. Qu and L. Peng, Org. Biomol. Chem., 2013, 11, 5000 DOI: 10.1039/C3OB40659H

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