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Issue 40, 2013
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ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

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Abstract

Isopropylamine is an ideal amino donor for reductive amination of carbonyl compounds by ω-transaminase (ω-TA) owing to its cheapness and high volatility of a ketone product. Here we developed asymmetric synthesis of unnatural amino acids via ω-TA-catalyzed amino group transfer between α-keto acids and isopropylamine.

Graphical abstract: ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

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Publication details

The article was received on 11 Mar 2013, accepted on 02 Jul 2013 and first published on 30 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB40495A
Citation: Org. Biomol. Chem., 2013,11, 6929-6933
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    ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

    E. Park, J. Dong and J. Shin, Org. Biomol. Chem., 2013, 11, 6929
    DOI: 10.1039/C3OB40495A

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