Issue 16, 2013

A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling–isomerization–condensation reaction

Abstract

A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.

Graphical abstract: A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling–isomerization–condensation reaction

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2013
Accepted
24 Feb 2013
First published
26 Feb 2013

Org. Biomol. Chem., 2013,11, 2574-2577

A novel convenient approach towards pyrrolo[1,2-b]pyridazines through a domino coupling–isomerization–condensation reaction

M. Wang, C. Tan, Q. He, Y. Xie and C. Yang, Org. Biomol. Chem., 2013, 11, 2574 DOI: 10.1039/C3OB40157J

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