Issue 3, 2013
From the journal:

Organic & Biomolecular Chemistry

Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines†

Yongsheng Zheng,ab   Zhouyang Xue,ab   Lixin Liu,ab   Chang Shu,ab   Weicheng Yuana  and  Xiaomei Zhang*a  

* Corresponding authors

a Key Laboratory for Asymmetric Synthesis and Chiral technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China
E-mail: xmzhang@cioc.ac.cn
Fax: (+86) 28-85257883
Tel: (+86) 28-85257883

b University of Chinese Academy of Sciences, Beijing, China

Abstract

By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, one of the products was employed in the synthesis of a pharmaceutical substance.

Graphical abstract: Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines

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Article information

DOI
https://doi.org/10.1039/C2OB26672E
Article type
Communication
Submitted
24 Aug 2012
Accepted
22 Nov 2012
First published
26 Nov 2012

Org. Biomol. Chem., 2013,11, 412-415

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Highly enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines

Y. Zheng, Z. Xue, L. Liu, C. Shu, W. Yuan and X. Zhang, Org. Biomol. Chem., 2013, 11, 412 DOI: 10.1039/C2OB26672E

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