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Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors

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a
Université Paris-Sud, CNRS, BioCIS UMR 8076, LabEx LERMIT, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry, France
E-mail: abdallah.hamze@u-psud.fr, mouad.alami@u-psud.fr;
Fax: +33-1-46835828 ;
Tel: +33-1-46835498
b
Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, avenue de la Terrasse, F-91198 Gif sur Yvette, France
c
Lebanese University, Laboratoire de Chimie Organique, Faculté de Pharmacie, Beirut-Hadath, Lebanon
Org. Biomol. Chem., 2013,11, 430-442

DOI: 10.1039/C2OB26253C
Received 02 Jul 2012, Accepted 19 Sep 2012
First published online 19 Sep 2012
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