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Issue 48, 2012
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Nickel-catalyzed C–P cross-coupling of diphenylphosphine oxide with aryl chlorides

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Abstract

A novel protocol for the preparation of various diarylphosphine oxide compounds via a Ni-catalyzed cross-coupling of aryl chlorides with R2P(O)H has been developed. Notably, this process exhibits the following very attractive features: (i) the process is simpler and operates under mild reaction conditions; (ii) the process is generally cheaper in part because the more accessible aryl chloride is used to form the C–P bond; (iii) the process avoids the need for simultaneous preparation and use of Ar2P(O)M.

Graphical abstract: Nickel-catalyzed C–P cross-coupling of diphenylphosphine oxide with aryl chlorides

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Publication details

The article was received on 28 Jul 2012, accepted on 23 Oct 2012 and first published on 24 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26874D
Citation: Org. Biomol. Chem., 2012,10, 9627-9633
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    Nickel-catalyzed C–P cross-coupling of diphenylphosphine oxide with aryl chlorides

    H. Zhang, M. Sun, Y. Ma, Q. Tian and S. Yang, Org. Biomol. Chem., 2012, 10, 9627
    DOI: 10.1039/C2OB26874D

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