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Issue 48, 2012
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Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

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Abstract

The synthesis of a series of carbohydrate–nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

Graphical abstract: Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

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Publication details

The article was received on 09 Aug 2012, accepted on 24 Oct 2012 and first published on 30 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26577J
Citation: Org. Biomol. Chem., 2012,10, 9601-9619
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    Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

    R. M. Deranieh, M. L. Greenberg, Pierre-B. Le Calvez, M. C. Mooney and M. E. Migaud, Org. Biomol. Chem., 2012, 10, 9601
    DOI: 10.1039/C2OB26577J

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