Issue 29, 2012
From the journal:

Organic & Biomolecular Chemistry

A polyoxapolyaza macrobicyclic receptor for the recognition of zwitterions†

Pedro Mateus,a   Rita Delgado,*a   Paula Brandãob  and  Vítor Félixc  

* Corresponding authors

a Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
E-mail: delgado@itqb.unl.pt
Tel: (+351) 214469737

b Departamento de Química, CICECO, Universidade de Aveiro, 3810-193 Aveiro, Portugal

c Departamento de Química, CICECO, and Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, 3810-193 Aveiro, Portugal

Abstract

A polyoxapolyaza heteroditopic macrobicyclic compound (btpN4O3) was synthesized. The acid–base behaviour of the compound as well as its binding ability for zwitterionic amino acids were studied by potentiometry at 298.2 ± 0.1 K in H2O–MeOH (50 : 50 v/v) and at I = 0.10 ± 0.01 M in NMe4TsO. The HnbtpN4O3n+ showed preference for amino acids containing tetrahedral anionic groups.

Graphical abstract: A polyoxapolyaza macrobicyclic receptor for the recognition of zwitterions

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Article information

DOI
https://doi.org/10.1039/C2OB25725D
Article type
Communication
Submitted
13 Apr 2012
Accepted
19 Jun 2012
First published
20 Jun 2012

Org. Biomol. Chem., 2012,10, 5529-5532

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A polyoxapolyaza macrobicyclic receptor for the recognition of zwitterions

P. Mateus, R. Delgado, P. Brandão and V. Félix, Org. Biomol. Chem., 2012, 10, 5529 DOI: 10.1039/C2OB25725D

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