Issue 22, 2012

Sulfoxide-mediated Umpolung of alkali halide salts

Abstract

A new protocol for the direct two-electron oxidative Umpolung of alkali halide salts is reported. This procedure, relying on the use of a commercially available sulfoxide as the oxidant, allows the electrophilic halogenation of carbonyl compounds as well as halolactonisation reactions to proceed from the corresponding sodium salts, at room temperature and under mild conditions.

Graphical abstract: Sulfoxide-mediated Umpolung of alkali halide salts

Supplementary files

Article information

Article type
Communication
Submitted
01 Mar 2012
Accepted
12 Mar 2012
First published
03 Apr 2012

Org. Biomol. Chem., 2012,10, 4327-4329

Sulfoxide-mediated Umpolung of alkali halide salts

S. Klimczyk, X. Huang, C. Farès and N. Maulide, Org. Biomol. Chem., 2012, 10, 4327 DOI: 10.1039/C2OB25459J

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