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Issue 1, 2012
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Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

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Abstract

An example of diastereoselective and enantioselective synthesis of thiochroman derivatives through a sulfa-Michael–Michael cascade sequence is disclosed. This is a significant complement of the quinine-thiourea catalyzed sulfa-Michael–Michael cascade reaction. The densely functionalized target thiochromans were obtained in high diastereoselectivities, and with high to excellent enantioselectivities.

Graphical abstract: Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

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Publication details

The article was received on 01 Sep 2011, accepted on 22 Sep 2011 and first published on 22 Sep 2011


Article type: Communication
DOI: 10.1039/C1OB06497E
Citation: Org. Biomol. Chem., 2012,10, 36-39
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    Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst

    Z. Du, C. Zhou, Y. Gao, Q. Ren, K. Zhang, H. Cheng, W. Wang and J. Wang, Org. Biomol. Chem., 2012, 10, 36
    DOI: 10.1039/C1OB06497E

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