Issue 22, 2011
From the journal:

Organic & Biomolecular Chemistry

Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature†

Dong-Chao Wang,a   Hong-Ying Niu,b   Gui-Rong Qu,*a   Lei Liang,a   Xue-Jiao Wei,a   Yang Zhanga  and  Hai-Ming Guo*a  

* Corresponding authors

a College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang, China
E-mail: quguir@sina.com, guohm518@hotmail.com
Fax: +86-3733329276

b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, China

Abstract

An efficient method for the synthesis of 6-alkyl or 6-aryl purines (nucleosides) was developed vianickel-catalyzed Negishi cross-couplings of 6-chloropurines and organozinc halides. The ligand-free process gave good to excellent isolated yields at room temperature.

Graphical abstract: Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature

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Article information

DOI
https://doi.org/10.1039/C1OB06265D
Article type
Communication
Submitted
27 Jul 2011
Accepted
18 Aug 2011
First published
18 Aug 2011

Org. Biomol. Chem., 2011,9, 7663-7666

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Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature

D. Wang, H. Niu, G. Qu, L. Liang, X. Wei, Y. Zhang and H. Guo, Org. Biomol. Chem., 2011, 9, 7663 DOI: 10.1039/C1OB06265D

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