Issue 14, 2011
From the journal:

Organic & Biomolecular Chemistry

Fast and efficient microwave-assisted synthesis of functionalized peptoids viaUgi reactions†‡

Angélica de Fátima S. Barreto,a   Otilie E. Vercillo,a   Mike A. Birkett,b   John C. Caulfield,b   Ludger A. Wessjohannc  and  Carlos Kleber Z. Andrade*a  

* Corresponding authors

a Laboratório de Química Metodológica e Orgânica Sintética (LaQMOS), Instituto de Química, Universidade de Brasília, C.P. 4478, Brasília, DF, Brasil
E-mail: ckleber@unb.br
Fax: +55(61) 32734149
Tel: 31073861

b Centre for Sustainable Pest and Disease Management, Biological Chemistry Department, Rothamsted Research, Harpenden, Hertfordshire, UK

c Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, Halle, (Saale), Germany

Abstract

A wide range of N-alkylglycines (peptoids) can be efficiently prepared viaUgi reactions using microwave irradiations. The results confirm the versatility and efficiency of the methodology for the preparation of functionalized peptoids. The products can be used in consecutive Ugi reactions to yield cyclic peptoids of potential biological interest.

Graphical abstract: Fast and efficient microwave-assisted synthesis of functionalized peptoids viaUgi reactions

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Article information

DOI
https://doi.org/10.1039/C1OB05471F
Article type
Communication
Submitted
24 Mar 2011
Accepted
16 May 2011
First published
16 May 2011

Org. Biomol. Chem., 2011,9, 5024-5027

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Fast and efficient microwave-assisted synthesis of functionalized peptoids viaUgi reactions

A. D. F. S. Barreto, O. E. Vercillo, M. A. Birkett, J. C. Caulfield, L. A. Wessjohann and C. K. Z. Andrade, Org. Biomol. Chem., 2011, 9, 5024 DOI: 10.1039/C1OB05471F

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