Issue 11, 2011

Polyethylene glycol-functionalized benzylidene cyclopentanonedyes for two-photon excited photodynamic therapy

Abstract

A series of polyethylene glycol-functionalized benzylidene cyclopentanone dyes with varying lipid/water partition coefficients were synthesized in high yields by a simple process. Detailed characterization and systematic studies of these molecules, including linear and nonlinear photophysical properties, reactive oxygen yields, and in vitro photodynamic therapy (PDT) activities, were conducted. Four of these dyes exhibited good solubility in PBS (>2 mg ml−1, which is sufficient for clinical venous injection), high reactive oxygen yields, large two-photon absorption and low dark toxicity, under the therapy dosage. Among them, two dyes could be absorbed efficiently by human rectal cancer 1116 cells, and presented strong two-photon excited PDT activity in in vitrocell experiments.

Graphical abstract: Polyethylene glycol-functionalized benzylidene cyclopentanone dyes for two-photon excited photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
31 Dec 2010
Accepted
10 Mar 2011
First published
11 Mar 2011

Org. Biomol. Chem., 2011,9, 4168-4175

Polyethylene glycol-functionalized benzylidene cyclopentanone dyes for two-photon excited photodynamic therapy

Y. Zhao, W. Wang, F. Wu, Y. Zhou, N. Huang, Y. Gu, Q. Zou and W. Yang, Org. Biomol. Chem., 2011, 9, 4168 DOI: 10.1039/C0OB01278E

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