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Issue 4, 2011
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Copper(I)-mediated preparation of new pyrano[3′,4′:4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

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Abstract

A general and efficient Cu(I)-mediated cross-coupling and heterocyclization reaction of 3-iodoimidazo[1,2-a]pyridine-2-carboxylic acid, and terminal alkynes was developed under very mild conditions. This method allows the introduction in one pot of a third ring fused in positions 2 and 3 of the imidazo[1,2-a]pyridine core with reasonable yields and total regioselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.

Graphical abstract: Copper(i)-mediated preparation of new pyrano[3′,4′:4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

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Publication details

The article was received on 24 Aug 2010, accepted on 03 Nov 2010 and first published on 20 Dec 2010


Article type: Paper
DOI: 10.1039/C0OB00622J
Citation: Org. Biomol. Chem., 2011,9, 1212-1218
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    Copper(I)-mediated preparation of new pyrano[3′,4′:4,5]imidazo[1,2-a]pyridin-1-one compounds under mild palladium-free conditions

    Z. Bahlaouan, M. Abarbri, A. Duchêne, J. Thibonnet, N. Henry, C. Enguehard-Gueiffier and A. Gueiffier, Org. Biomol. Chem., 2011, 9, 1212
    DOI: 10.1039/C0OB00622J

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