Issue 2, 2011
From the journal:

Organic & Biomolecular Chemistry

Convergent assembly of structurally diverse quinazolines†

Abel Crespo,a   Alberto Coelho,a   Paula M. Diz,a   Franco Fernández,b   Hector Novoa de Armasc  and  Eddy Sotelo*ab  

* Corresponding authors

a Combinatorial Chemistry Unit (COMBIOMED), Institute of Industrial Pharmacy (IFI), University of Santiago de Compostela, Santiago de Compostela 15782, Spain

b Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela 15782, Spain
E-mail: eddy.sotelo@usc.es
Fax: ++34-981-528093
Tel: ++34-981-563100

c Pharmaceutical Sciences Department, Johnson & Johnson, Pharmaceutical Research and Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

Abstract

A convergent and versatile Vilsmeier–Haack-based carbo-annulation strategy that exhibits an unusually elevated bond-forming efficiency has been developed. By virtue of its innovative approach, structure economy and simple execution conditions the methodology reported here constitutes a very attractive protocol that enables the rapid assembly of structurally diverse quinazoline chemotypes.

Graphical abstract: Convergent assembly of structurally diverse quinazolines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0OB00608D
Article type
Communication
Submitted
19 Aug 2010
Accepted
12 Oct 2010
First published
03 Nov 2010

Org. Biomol. Chem., 2011,9, 351-357

Permissions

Request permissions

Convergent assembly of structurally diverse quinazolines

A. Crespo, A. Coelho, P. M. Diz, F. Fernández, H. Novoa de Armas and E. Sotelo, Org. Biomol. Chem., 2011, 9, 351 DOI: 10.1039/C0OB00608D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements