Synthesis and bacterial biofilm inhibition studies of ethylN-(2-phenethyl) carbamate derivatives

Abstract

An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC₅₀ values.