Issue 14, 2010

Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

Abstract

The elaboration of biologically important 3,4-substituted pyrazolines was achieved by an organocatalysed aza-Michael/transimination domino sequence between hydrazones and enones making use of a mixture of heterogeneous resin-bound acid/base reagents. This methodology nicely illustrates the site isolation concept of supported reagents allowing the simultaneous use of otherwise destructive reactive functionalities.

Graphical abstract: Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2010
Accepted
10 May 2010
First published
26 May 2010

Org. Biomol. Chem., 2010,8, 3287-3293

Synthesis of pyrazolines by a site isolated resin-bound reagents methodology

V. Gembus, J. Bonnet, F. Janin, P. Bohn, V. Levacher and J. Brière, Org. Biomol. Chem., 2010, 8, 3287 DOI: 10.1039/C004704J

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