Issue 14, 2010

Total synthesis of decarestrictine I and botryolide B viaRCM protocol

Abstract

A convergent stereoselective total synthesis of decarestrictine I (1) and botryolide B (1a) invoking a common synthetic strategy is reported. The key steps are: ring-closing metathesis of epoxy dienoic esters obtained through the Yamaguchi esterification of their respective intermediates to furnish the respective Z-macrocycles (2 and 2a) which were further extrapolated to their respective targets.

Graphical abstract: Total synthesis of decarestrictine I and botryolide B via RCM protocol

Supplementary files

Article information

Article type
Communication
Submitted
23 Mar 2010
Accepted
27 May 2010
First published
08 Jun 2010

Org. Biomol. Chem., 2010,8, 3130-3132

Total synthesis of decarestrictine I and botryolide B via RCM protocol

P. Radha Krishna and T. J. Rao, Org. Biomol. Chem., 2010, 8, 3130 DOI: 10.1039/C004556J

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