Issue 14, 2010
From the journal:

Organic & Biomolecular Chemistry

Facile one-pot synthesis of three different substituted thiazoles from propargylic alcohols†

Xun Gao,a   Ying-ming Pan,a   Min Lin,a   Li Chena  and  Zhuang-ping Zhan*a  

* Corresponding authors

a Department of Chemistry, College of Chemistry and Chemical Engineering, and State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, Fujian, P. R. China
E-mail: zpzhan@xmu.edu.cn

Abstract

Three different substituted thiazoles have been successfully synthesized from readily available propargylic alcohols. Various secondary propargylic alcohols or tertiary propargylic alcohols participated well in the reaction, providing the desired products in good yields. This method provides a flexible and rapid route to substituted thiazoles.

Graphical abstract: Facile one-pot synthesis of three different substituted thiazoles from propargylic alcohols

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Article information

DOI
https://doi.org/10.1039/C002093A
Article type
Paper
Submitted
25 Feb 2010
Accepted
26 Apr 2010
First published
25 May 2010

Org. Biomol. Chem., 2010,8, 3259-3266

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Facile one-pot synthesis of three different substituted thiazoles from propargylic alcohols

X. Gao, Y. Pan, M. Lin, L. Chen and Z. Zhan, Org. Biomol. Chem., 2010, 8, 3259 DOI: 10.1039/C002093A

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